Since the opening of the first gallery in Paris in 1993, followed by the one in Brussels in 2008 and a second space in Paris in 2013, Nathalie Obadia has been exhibiting emerging and recognized artists from the international contemporary art scene. In the fall of 2021, Galerie Nathalie Obadia opened a new space in the Matignon-Saint-Honoré district of Paris.
For many years, the gallery has also participated in the rediscovery of deceased artists such as Martin Barré, Josep Grau-Garriga or Seydou Keita.

The gallery's mission is also to promote artists to institutions in France and abroad. Some examples to highlight the importance of artists' projects such as:

- Martin Barré, solo exhibition at the Musée des Beaux-Arts de Rouen, France (2023).
- Valérie Belin, solo exhibition at MUBA Eugène Leroy, Tourcoing, France (2023) and Musée des Beaux-Arts de Bordeaux, France (2024).
- Luc Delahaye, solo exhibition at the Jeu de Paume, Paris, France (2025).
- Roger-Edgar Gillet, solo exhibition at Espace Paul Rebeyrolle, Eymoutiers, France and travelling solo exhibition at the Musée des Beaux-Arts de Rennes, France (2026) and at the Musée Estrine, Saint-Rémy de Provence, France (2026).
- Patrick Faigenbaum, solo exhibition at the Musée de la Cristallerie Saint-Louis, France (2024).
- Josep Grau-Garriga, solo exhibition at MACBA, Barcelona, Spain (2023).
- Laura Henno, solo exhibitions at Centro Wifredo Lam, Havana, Cuba (2023) and CAC Passerelle, Brest, France (2023).
- Fabrice Hyber, solo exhibitions at the Domaine de Chaumont-sur-Loire, France (2023) and at the Espace

Louis Vuitton, Venice, Italy (2024).
- Shirley Jaffe, travelling solo exhibition at the KunstMuseum Basel, Switzerland (2023) and the Matisse Museum, Nice, France (2024).
- Seydou Keita, solo exhibition at the Brooklyn Museum, New York, USA (2024).
- Sophie Kuijken, solo exhibition at the Museum of Ixelles, Belgium (2024).
- Youssef Nabil, solo exhibition at LACMA, LA, USA (2025).
- Laure Prouvost, solo exhibition at the Kunsthalle Wien, Vienna, Austria (2023) and at the ACCA, Melbourne, Australia (2024).
- Sarkis, solo exhibition at ARTER, Istanbul, Turkey.
- Agnès Varda, solo exhibition at the Cinémathèque française, Paris, France (2023) and at the Musée Carnavalet, Paris, France (2025).
- Wang Keping, solo exhibition at Château de Chambord, France (2023).
- Jérôme Zonder, solo exhibition at Casino Luxembourg, Luxembourg (2024).

Galerie Nathalie Obadia participates in international art fairs: Art Basel, Art Basel Hong Kong, Art Basel Miami, Paris+ by Art Basel, Paris Photo, Art Geneva, Art Dubai, Art Brussels, Art Luxembourg, Art Paris, 1-54 Marrakech, TEFAF Maastricht, TEFAF New York among others.